Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application

• Juliana P. L. Gonçalves,
• Afnan Q. Shaikh,
• Manuela Reitzig,
• Daria A. Kovalenko,
• Jan Michael,
• René Beutner,
• Gianaurelio Cuniberti,
• Dieter Scharnweber and
• Jörg Opitz

Beilstein J. Org. Chem. 2014, 10, 2765–2773, doi:10.3762/bjoc.10.293

• on chemical modification of the nanodiamond surface with phosphate groups and their electrochemically assisted immobilization on titanium-based materials to increase adhesion at biomaterial surfaces. The starting material is detonation nanodiamond, which exhibits a heterogeneous surface due to the

• substrate. Keywords: biofunctionalization; carbon-nanomaterials; detonation nanodiamond; electrochemical immobilization; surface modification; titanium alloy; Introduction Detonation nanodiamonds (DND) are a promising carbon-derived nanoscale material, which has been investigated since some decades due to

Synthesis of nanodiamond derivatives carrying amino functions and quantification by a modified Kaiser test

• Gerald Jarre,
• Steffen Heyer,
• Elisabeth Memmel,
• Thomas Meinhardt and
• Anke Krueger

Beilstein J. Org. Chem. 2014, 10, 2729–2737, doi:10.3762/bjoc.10.288

• functionalization of nanodiamond with aromatic moieties carrying amino groups For the synthesis of a broad variety of aminated nanodiamond (ND) derivatives, a series of nanodiamond conjugates with different linker systems was synthesized starting from detonation nanodiamond 1 and thermally annealed nanodiamond 2 as